New research has observed the suppressive effects of resveratrol on inflammation and oxidative stress in humans – the first time such effects have been observed.
Oxidative stress and chronic inflammation are part of the root causes of many diseases such as cardiovascular diseases, insulin resistance, auto-immune diseases like rheumatoid arthritis, and Alzheimer's disease.
In the study, 20 healthy participants were randomized to receive placebo or 40mg of resveratrol over a six week period. Researchers observed that the resveratrol rich PCE suppressed reactive oxygen species generation, and also suppressed binding of the pro-inflammatory cytokine NFkB. The study also saw a significant reduction in the expression of tumor necrosis factor-alpha and interleukin-6, two major pro-inflammatory cytokines that are regulated by NFkB.
In parallel to these effects, the study witnessed a reduction in the expression of two major pro-inflammatory molecules (JNK-1 and IKKβ), leading to an anti-inflammatory response. The study also saw a reduction in the expression of SOCS-3, a protein that is modulated by pro-inflammatory cytokines.
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